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There are several matches for 'protein MutL'.
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5659 matches
showing page 1 of 283
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organism
protein
1)
Homo sapiens
MLH1 - DNA mismatch repair
protein
Mlh1; Heterodimerizes with PMS2 to form
MutL
alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then
MutL
alpha is recruited to the heteroduplex. Assembly of the
MutL
-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...]
[a.k.a. U17843, MLH1-226, ENST00000673713]
2)
Homo sapiens
CCNB1IP1 - E3 ubiquitin-
protein
ligase CCNB1IP1; Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by
MutL
-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates [...]
[a.k.a. C14orf18, CCNB1IP1-206, CCNB1IP1-203]
3)
Homo sapiens
MSH6 - DNA mismatch repair
protein
Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the
MutL
alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, a [...]
[a.k.a. HPA028446, XP_024308589.1, XP_024308590]
4)
Homo sapiens
MSH3 - DNA mismatch repair
protein
Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the
MutL
alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, a [...]
[a.k.a. AC010270, DNA mismatch repair protein Msh3, 3THW]
5)
Mus musculus
Mlh1 - DNA mismatch repair
protein
Mlh1; Heterodimerizes with Pms2 to form
MutL
alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then
MutL
alpha is recruited to the heteroduplex. Assembly of the
MutL
-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...]
[a.k.a. XP_006512014, Q9JK91, NM_026810]
6)
Mus musculus
Ccnb1ip1 - E3 ubiquitin-
protein
ligase CCNB1IP1; Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by
MutL
-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels [...]
[a.k.a. NP_001104589.1, Cyclin B1 interacting protein 1, Hei10]
7)
Mus musculus
Msh6 - DNA mismatch repair
protein
Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the
MutL
alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, a [...]
[a.k.a. U61389, Q6GTK8, AAC53034.1]
8)
Mus musculus
Msh3 - DNA mismatch repair
protein
Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the
MutL
alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, a [...]
[a.k.a. NP_034959.2, ENSMUSP00000139620, ENSMUST00000190761.1]
9)
Escherichia coli K12
mutL - Methyl-directed mismatch repair
protein
; This
protein
is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a
protein
that promotes the formation of a stable complex between two or more DNA-binding
proteins
in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of
MutL
is stimulated by DNA.
[a.k.a. AAC77127.1, b4170, NZ_STEB01000013.1]
10)
Saccharomyces cerevisiae
PMS1 - ATP-binding
protein
required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli
MutL
.
[a.k.a. YNL082W, sce:YNL082W, 4E4W]
11)
Actinokineospora spheciospongiae
UO65_0040 -
Protein
mutL
.
[a.k.a. EWC64634.1,
Protein mutL
, EWC64634]
12)
Alloactinosynnema sp. L07
CRK59715.1 -
Protein
mutL
.
[a.k.a. gene:80948592,
Protein mutL
, A0A0H5D527_9PSEU]
13)
Desulfotomaculum hydrothermale
mutL -
Protein
mutL
.
[a.k.a. DESHY_160080, CCO07956.1,
Protein mutL
]
14)
Firmicutes bacterium CAG227
CDC94616.1 -
Protein
MutL
; Product inferred by homology to UniProt.
[a.k.a. BN546_00747, R6VRA8,
protein MutL
,
Protein MutL
]
15)
Kibdelosporangium sp. MJ126NF4
CEL22074.1 -
Protein
mutL
.
[a.k.a. gene:203539104, CEL22074,
Protein mutL
]
16)
Sporomusa ovata
mutL1 -
Protein
MutL
.
[a.k.a. EQB28802.1, SOV_1c05250,
protein MutL
,
Protein MutL
]
17)
Sporomusa ovata
mutL2 -
Protein
MutL
.
[a.k.a. EQB28953.1, SOV_1c06790,
protein MutL
,
Protein MutL
]
18)
Tepidanaerobacter acetatoxydans
mutL - TIGRFAM: Conserved hypothetical protein CHP01319, GlmL; KEGG: aar:Acear_0478 hypothetical protein.
[a.k.a. TepRe1_0113, AEE90324.1, WP_013777248.1,
Protein MutL
]
19)
Thermacetogenium phaeum
mutL2 -
Protein
MutL
.
[a.k.a. Tph_c20270, AFV12221.1, AFV12221,
protein MutL
,
Protein MutL
, ...]
20)
Treponema phagedenis
mutL -
Protein
MutL
.
[a.k.a. TPHV1_150020, CEM61138.1, HMPREF9554_02022,
Protein MutL
]
5659 matches
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